HIV-1 Env- and Vpu-specific antibody-dependent cellular cytotoxicity responses associated with elite control of HIV

V Madhavi; BD Wines; J Amin; S Emery; E Lopez; A Kelleher; RJ Center; P Mark Hogarth; AW Chung; SJ Kent; I Stratov

Journal article

HIV-1 Env- and Vpu-specific antibody-dependent cellular cytotoxicity responses associated with elite control of HIV

V Madhavi, BD Wines, J Amin, S Emery, E Lopez, A Kelleher, RJ Center, P Mark Hogarth, AW Chung, SJ Kent, I Stratov

Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2017

DOI: 10.1128/JVI.00700-17

Abstract

Studying HIV-infected individuals who control HIV replication (elite controllers [ECs]) enables exploration of effective anti-HIV immunity. HIV Env-specific and non- Env-specific antibody-dependent cellular cytotoxicity (ADCC) may contribute to protection from progressive HIV infection, but the evidence is limited. We recruited 22 ECs and matched them with 44 viremic subjects. HIV Env- and Vpu-specific ADCC responses in sera were studied using a novel enzyme-linked immunosorbent assay (ELISA)-based dimeric recombinant soluble FcγRIIIa (rsFcγRIIIa)-binding assay, surface plasmon resonance, antibody-dependent natural killer (NK) cell activation assays, and ADCC-mediated killing assays. ECs had..

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University of Melbourne Researchers

Amy Chung Author

Stephen Kent Author

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HIV LATENCY PATHOGENESIS AND IMMUNITY

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Grants

Awarded by Department of Health

Funding Acknowledgements

This project was supported by the Australia-India Strategic Research Fund (AISRF grant 08020), the Australian National Health and Medical Research Council (NHMRC program grant 1052979), and the Australian Department of Health.